Jazz Pharmaceuticals Announces Third Quarter 2025 Financial Results and Updates 2025 Financial Guidance

Modeyso™ approved as the first and only treatment for recurrent H3 K27M-mutant DMG –

Zepzelca® and atezolizumab (Tecentriq®) combination approved as maintenance therapyin 1L ES-SCLC –

3Q25 total revenues increased 7% year-over-year driven by robust growth ofEpidiolex®, Xywav® and the launch of Modeyso –

Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced financial results for the third quarter of 2025 and updated financial guidance for 2025.

“Achieving the highest revenue quarter in Jazz's history speaks to the strength of our diversified portfolio and the outstanding performance of our team. We were pleased to once again deliver solid execution across our sleep, epilepsy and oncology portfolios, led by double-digit percentage growth from Epidiolex and Xywav,” said Renee Gala, president and chief executive officer of Jazz Pharmaceuticals. “In addition, we achieved several key milestones that will enhance our commercial portfolio, including receiving FDA approvals for Modeyso as well as the Zepzelca and atezolizumab first-line maintenance combination. We remain confident in the opportunity presented by zanidatamab and look forward to sharing the top-line data readout from the Phase 3 HERIZON-GEA-01 trial before the end of the year. With a proven portfolio and strong financial foundation, we are well-positioned to accelerate our evolution and deliver meaningful value for patients and shareholders alike.”

Key Highlights

— Modeysoreceived accelerated approval from the FDA ahead of its PDUFA date; initiated commercial launch in August 2025 with strong initial uptake and sales of $11.0 million in 3Q25.

— Zepzelcaand atezolizumab combination received FDA approval for 1L maintenance treatment of ES-SCLC based on positive data from the Phase 3 IMforte trial.

— Top-linePFS data from zanidatamab in Phase 3 1L GEA expected in 4Q25; updated intent-to-treat population for PFS to include all patients enrolled in the trial.

— Narrowed 2025 total revenue guidance range to $4.175 – $4.275 billion from $4.150 – $4.300 billion.

— Announced the appointment of Dr. Ted Love to the Board of Directors.

Business Updates

Xywav (calcium, magnesium, potassium, and sodium oxybates) oral solution:

— Net product sales increased 11% to $431.4 million in 3Q25 compared to 3Q24.

— Meaningful net patient adds in 3Q25 of approximately 450 patients. There were approximately 15,675 active patients exiting the quarter comprised of approximately 10,725 narcolepsy patients and approximately 4,950 idiopathic hypersomnia (IH) patients.

Epidiolex/Epidyolex® (cannabidiol):

— Net product sales increased 20% to $302.6 million in 3Q25 compared to 3Q24.

— In 3Q25, volumes increased by 10%, driven by demand, and net product salesbenefitted from lower gross to net deductions in the U.S.

Rylaze®/Enrylaze® (asparaginase erwinia chrysanthemi (recombinant)-rywn):

— Net product sales increased 1% to $99.9 million in 3Q25 compared to 3Q24.

Zepzelca (lurbinectedin):

— Net product sales decreased 8% to $79.3 million in 3Q25 compared to 3Q24.

— Zepzelca and atezolizumab combination was included in National Comprehensive Cancer Network® (NCCN®) Clinical Practice Guidelines in Oncology as a preferred regimen for patients whose disease has not progressed following four cycles of platinum-based chemotherapy and atezolizumab induction.

Ziihera® (zanidatamab-hrii):

— Net product sales were $8.3 million in 3Q25 following product launch in December 2024.

— Updated the intent-to-treat population for the primaryPFS (progression-free survival) and interim overall survival analyses of the HERIZON-GEA-01 trial to include the full patient population enrolled in the trial.

Modeyso (dordaviprone):

— Net product sales were $11.0 million in 3Q25 following product launch in August 2025.

— Modeysowas made commercially available quickly following FDAaccelerated approval on August6,ensuring patients with H3 K27M-mutant diffuse midline glioma (DMG) had access to the first and only targeted drug therapy for this ultra-rare and aggressive brain tumor.

— Modeysowas included in the NCCN® Clinical Practice Guidelines in Oncology.

Corporate Development:

— The Company announced a global licensing agreement with Saniona to develop and commercialize SAN2355, a highly differentiated, subtype selective Kv7.2/Kv7.3 activator in preclinical development for epilepsy and other potential indications.

Financial Highlights

Three Months Ended Nine Months Ended September 30, September 30,(In thousands, except per share amounts) 2025 2024 2025 2024Total revenues $ 1,126,107 $ 1,054,969 $ 3,069,660 $ 2,980,777GAAP net income (loss) $ 251,412 $ 215,055 $ (559,599) $ 369,005Non-GAAP adjusted net income1 $ 500,653 $ 412,359 $ 101,037 $ 951,445GAAP earnings (loss) per share $ 4.08 $ 3.42 $ (9.18) $ 5.63Non-GAAP adjusted earnings per share1 $ 8.13 $ 6.54 $ 1.63 $ 14.25

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1. Commencing with the first quarter of 2025, we are no longer including an adjustment for non-cash interest expense in the Company's non-GAAP adjusted financial measures and for the purposes of comparability, non-GAAP adjusted financial measures for the 2024 periods have been updated to reflect this change. See “Non-GAAP Financial Measures” below.

Reconciliations of applicable GAAP reported to non-GAAP adjusted information are included at the end of this press release.

Total Revenues

Three Months Ended Nine Months Ended September 30, September 30,(In thousands) 2025 2024 2025 2024Xywav $ 431,410 $ 388,466 $ 1,191,535 $ 1,072,238Xyrem 35,663 58,114 108,253 184,526Epidiolex/Epidyolex 302,608 251,558 772,075 697,376Sativex 4,752 4,586 14,774 13,704Total Neuroscience 774,433 702,724 2,086,637 1,967,844Rylaze/Enrylaze 99,868 98,780 294,760 309,359Zepzelca 79,295 85,843 216,869 241,990Defitelio/defibrotide 51,752 65,818 140,520 158,915Vyxeos 37,583 34,313 111,978 109,348Ziihera 8,306 – 16,272 -Modeyso 11,032 – 11,502 -Total Oncology 287,836 284,754 791,901 819,612Other 2,143 2,229 10,863 8,497Product sales, net 1,064,412 989,707 2,889,401 2,795,953High-sodium oxybate AG royalty revenue 52,945 58,157 156,029 162,268Other royalty and contract revenues 8,750 7,105 24,230 22,556Total revenues $ 1,126,107 $ 1,054,969 $ 3,069,660 $ 2,980,777

Total revenues increased 7% in 3Q25 compared to the same period in 2024.

Total neuroscience revenue, including high-sodium oxybate AG royalty revenue, increased 9% to $827.4million in 3Q25, compared to 3Q24. The increase in 3Q25 was due to higher Epidiolex/Epidyolex and Xywav net product sales, partially offset by decreased Xyrem net product sales.

Oncology net product sales increased 1% to $287.8 million in 3Q25, compared to3Q24, due to the inclusion of Modeyso and Ziihera net product sales, offset by lower net product sales of Defitelio/defibrotide and Zepzelca.

Operating Expenses and Income Tax (Benefit) Expense

Three Months Ended Nine Months Ended September 30, September 30,(In thousands, except percentages) 2025 2024 2025 2024GAAP:Cost of product sales $ 128,880 $ 111,611 $ 349,768 $ 317,000Gross margin 87.9% 88.7% 87.9% 88.7%Selling, general and administrative $ 530,647 $ 325,772 $ 1,403,059 $ 1,016,007% of total revenues 47.1% 30.9% 45.7% 34.1%Research and development $ 198,203 $ 199,919 $ 568,827 $ 643,500% of total revenues 17.6% 19.0% 18.5% 21.6%Acquired in-process research and development $ 42,500 $ – $ 947,862 $ 10,000Income tax benefit $ (242,424) $ (14,533) $ (277,406) $ (33,517)Effective tax rate N/A(1) (7.2)% 33.2% (9.9)%

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1. Not a meaningful metric due to minimal profit before tax in this period. Three Months Ended Nine Months Ended September 30, September 30,(In thousands, except percentages) 2025 2024 2025 2024Non-GAAP adjusted:Cost of product sales $ 83,176 $ 72,844 $ 229,175 $ 209,405Gross margin 92.2% 92.6% 92.1% 92.5%Selling, general and administrative $ 460,061 $ 288,672 $ 1,242,722 $ 903,557% of total revenues 40.9% 27.4% 40.5% 30.3%Research and development $ 169,977 $ 180,992 $ 496,730 $ 588,470% of total revenues 15.1% 17.2% 16.2% 19.7%Acquired in-process research and development $ 42,500 $ – $ 947,862 $ 10,000Income tax (benefit) expense $ (178,781) $ 40,414 $ (100,096) $ 127,528Effective tax rate (55.5)% 8.9% N/A(1) 11.8%

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1. Not a meaningful metric due to minimal profit before tax in this period.

Changes in operating expenses and income tax (benefit) expense in 3Q25 over the prior year period are primarily due to the following:

— Cost of product sales, on a GAAP and non-GAAP adjusted basis, increased in 3Q25 compared to 3Q24, primarily due to higher inventory provisions and changes in product mix. Cost of product sales, on a GAAP basis, included higher acquisition accounting inventory fair value step-up expense in 3Q25 as compared to 3Q24.

— Selling, general and administrative (SG&A) expenses, on a GAAP and non-GAAP adjusted basis, increased in 3Q25 compared to 3Q24, primarily due to the Avadel litigation settlement of $90.0million and a Xyrem antitrust litigation settlement of $61.5 million, and, to a lesser extent, higher compensation-related expenses driven by higher headcount along with increased investment in sales and marketing in support of our commercial portfolio. SG&A expenses, on a GAAP basis, also included increased share-based compensation expense.

— Research and development (R&D) expenses, on a GAAP and non-GAAP adjusted basis, decreased in 3Q25 compared to 3Q24, primarily due to lower clinical study costs primarily related tozanidatamab as a result of timing of clinical trial activities, JZP385 (essential tremor) following discontinuation of this program, and JZP258 (XYLO/DUET) due to the completion of this trial in the first half of 2025, partially offset by the addition of costs relating to Modeyso following the Chimerix acquisition. R&D expenses, on a GAAP basis, included integration expenses related to the Chimerix acquisition of $6.5 million.

— Acquired in-process research and development (IPR&D) in 3Q25, on a GAAP and non-GAAP adjusted basis, represents the upfront payment made in connection with our global license agreement with Saniona.

— Income tax benefit in 3Q25, on a GAAP and non-GAAP adjusted basis, included a benefit of $205.9 million on recognition of certain U.S. federal and state deferred tax assets acquired through theChimerix acquisition.

Cash Flow and Balance Sheet As of September30, 2025, cash, cash equivalents and investments were $2.0billion, and the outstanding principal balance of the Company's long-term debt was $5.4billion. In addition, the Company had undrawn borrowing capacity under a revolving credit facility of $885.0million. For the nine months ended September30,2025, the Company generated $993.3million of cash from operations reflecting strong business performance and continued financial discipline.

2025 Financial Guidance Jazz Pharmaceuticals has updated its full-year 2025 financial guidance as follows:

Guidance provided as of(In millions) November 5, 2025 August 5, 2025Total Revenues $4,175 – $4,275 $4,150 – $4,300

GAAP:

(In millions, except per share amounts and percentages) November 5, 2025 August 5, 2025Gross margin % 88% 88%SG&A expenses $1,786 – $1,846 $1,620 – $1,693R&D expenses $771 – $810 $805 – $865Acquired IPR&D $948 $905Effective tax rate 35% – 45% 4% – 16%Net loss $(435) – $(315)1 $(565) – $(450)Net loss per diluted share $(7.10) – $(5.20)1 $(9.25) – $(7.50)Weighted-average ordinary shares used in per share calculations 61 61 – 62

Non-GAAP adjusted:

(In millions, except per share amounts and percentages) November 5, 2025 August 5, 2025Gross margin % 92%2,6 92%SG&A expenses $1,590 – $1,6303,6 $1,450 – $1,500R&D expenses $680 – $7104,6 $730 – $780Acquired IPR&D $948 $905Effective tax rate (20)% – (15)%5,6 27% – 37%Net income $475 – $5251,6 $300 – $350Net income per diluted share $7.65 – $8.451,6 $4.80 – $5.60Weighted-average ordinary shares used in per share calculations 62 62 – 63

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1. The projected GAAP net loss and non-GAAP adjusted net income include acquired IPR&D expenses of $947.9 million, litigation settlement expenses of $323.5 million and an income tax benefit of $205.9 million, which impact the Company's projected results by $1.0 billion (net of tax of $54.8 million), or $16.40 per share and $16.30 per share, on a GAAP and on a non-GAAP adjusted basis, respectively.2. Excludes $135-$155 million of amortization of acquisition accounting inventory fair value step-up, and $18-$19 million of share-based compensation expense.3. Excludes $179-$192 million of share-based compensation expense and $17-$24 million of integration related expenses.4. Excludes $83-$89 million of share-based compensation expense and $8-$11 million of integration related expenses.5. Excludes 50%-65% from the GAAP effective tax rate of 35%-45% relating to the income tax effect of adjustments between GAAP net loss and non-GAAP adjusted net income, resulting in a non-GAAP adjusted effective tax rate of (20)%-(15)%.6. See “Non-GAAP Financial Measures” below. Reconciliations of non-GAAP adjusted guidance measures are included above and in the table titled “Reconciliation of 2025 GAAP Net Loss and Diluted LPS to Non-GAAP Adjusted Net Income and Diluted EPS Guidance” at the end of this press release.

Conference Call Details Jazz Pharmaceuticals will host an investor conference call and live audio webcast today at 4:30 p.m. EST (9:30 p.m. GMT) to provide a business and financial update and discuss its 2025 third quarter results.

Interested parties may register for the call here or via the Investors section of the Jazz Pharmaceuticals website at www.jazzpharmaceuticals.com. To ensure a timely connection, it is recommended that participants register at least 15 minutes prior to the scheduled webcast.

A replay of the webcast will be available via the Investors section of the Jazz Pharmaceuticals website at www.jazzpharmaceuticals.com.

About Jazz Pharmaceuticals Jazz Pharmaceuticals plc (NASDAQ: JAZZ) is a global biopharmaceutical company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases – often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit www.jazzpharmaceuticals.com for more information.

Non-GAAP Financial Measures To supplement Jazz Pharmaceuticals' financial results and guidance presented in accordance with U.S. generally accepted accounting principles (GAAP), the Company uses certain non-GAAP (also referred to as adjusted or non-GAAP adjusted) financial measures in this press release and the accompanying tables. In particular, the Company presents non-GAAP adjusted net income (and the related per share measure) and its line-item components, as well as certain non-GAAP adjusted financial measures derived therefrom, including non-GAAP adjusted gross margin percentage and non-GAAP adjusted effective tax rate. Non-GAAP adjusted net income (and the related per share measure) and its line-item components exclude from GAAP reported net income (loss) (and the related per share measure) and its line-item components certain items, as detailed in the reconciliation tables that follow, and in the case of non-GAAP adjusted net income (and the related per share measure), adjust for the income tax effect of the non-GAAP adjustments. In this regard, the components of non-GAAP adjusted net income, including non-GAAP adjusted cost of product sales, SG&A expenses and R&D expenses, are income statement line items prepared on the same basis as, and therefore components of, the overall non-GAAP adjusted net income measure.

The Company believes that each of these non-GAAP financial measures provides useful supplementary information to, and facilitates additional analysis by, investors and analysts and that each of these non-GAAP financial measures, when considered together with the Company's financial information prepared in accordance with GAAP, can enhance investors' and analysts' ability to meaningfully compare the Company's results from period to period, to its forward-looking guidance, and to identify operating trends in the Company's business. In addition, these non-GAAP financial measures are regularly used by investors and analysts to model and track the Company's financial performance. Jazz Pharmaceuticals' management also regularly uses these non-GAAP financial measures internally to understand, manage and evaluate the Company's business and to make operating decisions, and compensation of executives is based in part on certain of these non-GAAP financial measures. Because these non-GAAP financial measures are important internal measurements for Jazz Pharmaceuticals' management, the Company also believes that these non-GAAP financial measures are useful to investors and analysts since these measures allow for greater transparency with respect to key financial metrics the Company uses in assessing its own operating performance and making operating decisions. These non-GAAP financial measures are not meant to be considered in isolation or as a substitute for comparable GAAP measures; should be read in conjunction with the Company's consolidated financial statements prepared in accordance with GAAP; have no standardized meaning prescribed by GAAP; and are not prepared under any comprehensive set of accounting rules or principles in the reconciliation tables that follow. In addition, from time to time in the future there may be other items that the Company may exclude for purposes of its non-GAAP financial measures; and the Company has ceased, and may in the future cease, to exclude items that it has historically excluded for purposes of its non-GAAP financial measures. In this regard, commencing with the first quarter of 2025, the Company is no longer including an adjustment for non-cash interest expense in the Company's non-GAAP adjusted financial measures. For purposes of comparability, non-GAAP adjusted financial measures for the 2024 periods have been updated to reflect this change. Likewise, the Company may determine to modify the nature of its adjustments to arrive at its non-GAAP financial measures. Because of the non-standardized definitions of non-GAAP financial measures, the non-GAAP financial measures as used by Jazz Pharmaceuticals in this press release and the accompanying tables have limits in their usefulness to investors and may be calculated differently from, and therefore may not be directly comparable to, similarly titled measures used by other companies.

Caution Concerning Forward-Looking Statements This press release contains forward-looking statements, including, but not limited to, statements related to: the Company's growth prospects and future financial and operating results, including the Company's 2025 financial guidance and the Company's expectations related thereto, including with respect to anticipated catalysts; expectations with respect to the transition of the CEO role; anticipated multiple near-term pipeline catalysts that each represent significant opportunities to drive greater revenue and create long-term value; expectations that Epidiolex will achieve blockbuster status in 2025; anticipated benefits and expenses relating to the Company's acquisition of Chimerix; the Company's advancement of pipeline programs and the timing of development activities, regulatory activities and submissions related thereto; the potential of the ongoing Phase 3 ACTION trial to confirm clinical benefit of Modeyso in recurrent H3 K27M-mutant diffuse glioma and extend to use in first-line patients; planned or anticipated clinical trial events, including with respect to initiations, enrollment and data read-outs, and the anticipated timing thereof, including: top-line PFS data from a Phase 3 trial of zanidatamab in 1L GEA; and the Company's development, regulatory and commercialization strategy; the Company's expectations with respect to its products and product candidates and the potential of the Company's products and product candidates and the potential regulatory path related thereto; including Zepzelca's potential to change current practice as maintenance therapy in 1L ES-SCLC and Modeyso's potential to be a meaningful and durable revenue opportunity; the Company's capital allocation and corporate development strategy; the potential successful future development, manufacturing, regulatory and commercialization activities; the Company's ability to realize the commercial potential of its products; the Company's net product sales and goals for net product sales from new and acquired products; the Company's views and expectations relating to its patent portfolio, including with respect to expected patent protection, as well as expectations with respect to exclusivity; the Company's clinical trials confirming clinical benefit or enabling regulatory submissions; planned or anticipated regulatory submissions and filings, and the anticipated timing thereof; potential regulatory approvals; and other statements that are not historical facts. These forward-looking statements are based on the Company's current plans, objectives, estimates, expectations and intentions and inherently involve significant risks and uncertainties.

Actual results and the timing of events could differ materially from those anticipated in such forward- looking statements as a result of these risks and uncertainties, which include, without limitation, risks and uncertainties associated with: maintaining or increasing sales of, and revenue from, Xywav, Rylaze and Epidiolex/Epidyolex and other marketed products; the introduction of new products into the U.S. market that compete with, or otherwise disrupt the market for the Company's products and product candidates; effectively launching and commercializing the Company's other products and product candidates; the successful completion of development and regulatory activities with respect to the Company's product candidates; obtaining and maintaining adequate coverage and reimbursement for the Company's products; the time-consuming and uncertain regulatory approval process, including the risk that the Company's current and/or planned regulatory submissions may not be submitted, accepted or approved by applicable regulatory authorities in a timely manner or at all; the costly and time-consuming pharmaceutical product development and the uncertainty of clinical success, including risks related to failure or delays in successfully initiating or completing clinical trials and assessing patients; global economic, financial, and healthcare system disruptions and the current and potential future negative impacts to the Company's business operations and financial results; geopolitical events, including international tariffs and trade restrictions and the conflict between Russia and Ukraine and related sanctions; macroeconomic conditions, including global financial markets, rising interest rates and inflation and recent and potential banking disruptions; regulatory initiatives and changes in tax laws; market volatility; protecting and enhancing the Company's intellectual property rights and the Company's commercial success being dependent upon the Company obtaining, maintaining and defending intellectual property protection and exclusivity for its products and product candidates; delays or problems in the supply or manufacture of the Company's products and product candidates; complying with applicable U.S. and non-U.S. regulatory requirements, including those governing the research, development, manufacturing and distribution of controlled substances; government investigations, legal proceedings and other actions; identifying and consummating corporate development transactions, financing these transactions and successfully integrating acquired products and product candidates, products and businesses, including Chimerix and the acquired product Modeyso; the Company's ability to realize the anticipated benefits of its corporate development transactions and its collaborations and license agreements with third parties; the sufficiency of the Company's cash flows and capital resources; the Company's ability to achieve targeted or expected future financial performance and results and the uncertainty of future tax, accounting and other provisions and estimates; the Company's ability to meet its projected long-term goals and objectives, in the time periods that the Company anticipates, or at all, and the inherent uncertainty and significant judgments and assumptions underlying the Company's long-term goals and objectives; fluctuations in the market price and trading volume of the Company's ordinary shares; the timing and availability of alternative investment opportunities; and other risks and uncertainties affecting the Company, including those described from time to time under the caption “Risk Factors” and elsewhere in Jazz Pharmaceuticals' Securities and Exchange Commission filings and reports, including the Company's Annual Report on Form 10-K for the year ended December 31, 2024, as supplemented by the Company's Quarterly Report on Form 10-Q for the quarter ended March 31, 2025, the Company's Quarterly Report on Form 10-Q for the quarter ended June 30, 2025 and future filings and reports by the Company, including the Company's Quarterly Report on Form 10-Q for the quarter ended September 30, 2025. Other risks and uncertainties of which the Company is not currently aware may also affect the Company's forward-looking statements and may cause actual results and the timing of events to differ materially from those anticipated.

JAZZ PHARMACEUTICALSPLCCONDENSED CONSOLIDATED STATEMENTS OF INCOME (LOSS)(In thousands, except per share amounts)(Unaudited) Three Months Ended Nine Months Ended September 30, September 30, 2025 2024 2025 2024Revenues:Product sales, net $ 1,064,412 $ 989,707 $ 2,889,401 $ 2,795,953Royalties and contract revenues 61,695 65,262 180,259 184,824Total revenues 1,126,107 1,054,969 3,069,660 2,980,777Operating expenses:Cost of product sales (excluding amortization of 128,880 111,611 349,768 317,000acquired developed technologies)Selling, general and administrative 530,647 325,772 1,403,059 1,016,007Research and development 198,203 199,919 568,827 643,500Intangible asset amortization 168,368 157,457 484,919 468,410Acquired in-process research and development 42,500 – 947,862 10,000Total operating expenses 1,068,598 794,759 3,754,435 2,454,917Income (loss) from operations 57,509 260,210 (684,775) 525,860Interest expense, net (48,576) (58,702) (149,645) (186,841)Foreign exchange gain (loss) 102 (701) (1,910) (1,887)Income (loss) before income tax benefit and equity in 9,035 200,807 (836,330) 337,132loss of investeesIncome tax benefit (242,424) (14,533) (277,406) (33,517)Equity in loss of investees 47 285 675 1,644Net income (loss) $ 251,412 $ 215,055 $ (559,599) $ 369,005Net income (loss) per ordinary share:Basic $ 4.14 $ 3.50 $ (9.18) $ 5.93Diluted $ 4.08 $ 3.42 $ (9.18) $ 5.63Weighted-average ordinary shares used in per share 60,696 61,414 60,955 62,275calculations – basicWeighted-average ordinary shares used in per share 61,606 63,174 60,955 67,511calculations – dilutedJAZZ PHARMACEUTICALS PLCCONDENSED CONSOLIDATED BALANCE SHEETS(In thousands)(Unaudited) September 30, December 31, 2025 2024ASSETSCurrent assets:Cash and cash equivalents $ 1,326,070 $ 2,412,864Investments 720,000 580,000Accounts receivable, net of allowances 764,364 716,765Inventories 483,111 480,445Prepaid expenses 146,892 177,411Other current assets 315,441 261,543Total current assets 3,755,878 4,629,028Property, plant and equipment, net 188,913 173,413Operating lease assets 61,204 53,582Intangible assets, net 4,565,737 4,755,695Goodwill 1,827,483 1,716,323Deferred tax assets, net 846,168 560,245Deferred financing costs 8,034 9,489Other non-current assets 103,068 114,482Total assets $ 11,356,485 $ 12,012,257LIABILITIES AND SHAREHOLDERS' EQUITYCurrent liabilities:Accounts payable $ 152,227 $ 77,869Accrued liabilities 1,001,556 910,947Current portion of long-term debt 1,029,179 31,000Income taxes payable 91,140 18,757Total current liabilities 2,274,102 1,038,573Long-term debt, less current portion 4,331,982 6,077,640Operating lease liabilities, less current portion 53,426 38,938Deferred tax liabilities, net 629,033 676,736Other non-current liabilities 108,912 86,614Total shareholders' equity 3,959,030 4,093,756Total liabilities and shareholders' equity $ 11,356,485 $ 12,012,257JAZZ PHARMACEUTICALS PLCSUMMARY OF CASH FLOWS(In thousands)(Unaudited) Nine Months Ended September 30, 2025 2024Net cash provided by operating activities $ 993,255 $ 997,328Net cash used in investing activities (1,137,751) (314,908)Net cash provided by (used in) financing activities (948,820) 28,791Effect of exchange rates on cash and cash equivalents 6,522 614Net increase (decrease) in cash and cash equivalents $ (1,086,794) $ 711,825JAZZ PHARMACEUTICALS PLCRECONCILIATIONS OF GAAP REPORTED TO NON-GAAP ADJUSTED INFORMATION(In thousands, except per share amounts)(Unaudited) Three Months Ended Nine Months Ended September 30, September 30, 2025 2024 2025 2024 Net Diluted Net Diluted Net Diluted EPS/(Loss) Net Diluted Income Earnings Income EPS1 Income Per Share Income EPS1 Per Share (Loss) (LPS) (EPS)GAAP reported $ 251,412 $ 4.08 $ 215,055 $ 3.42 $ (559,599) $ (9.18) $ 369,005 $ 5.63Intangible asset 168,368 2.73 157,457 2.49 484,919 7.83 468,410 6.94amortizationShare-based 88,125 1.43 59,760 0.95 220,279 3.56 177,855 2.63compensation expenseAcquisition accounting 40,355 0.66 35,034 0.55 107,344 1.73 97,220 1.44inventory fair value step-upIntegration related 16,036 0.26 – – 25,404 0.41 – -expenses2Income tax effect of (63,643) (1.03) (54,947) (0.87) (177,310) (2.86) (161,045) (2.39)above adjustmentsEffect of potentially – – – – – 0.14 – -dilutive ordinary shareson non-GAAP adjusted EPS1Non-GAAP adjusted $ 500,653 $ 8.13 $ 412,359 $ 6.54 $ 101,037 $ 1.63 $ 951,445 $ 14.25Weighted-average 61,606 63,174 60,955 67,511ordinary shares used indiluted per sharecalculations – GAAP1Dilutive effect of – – 951 -employee equityincentive and purchaseplansWeighted-average ordinary 61,606 63,174 61,906 67,511shares used in diluted pershare calculations – non-GAAP1

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Explanation of Adjustments and Certain Line Items:

1. Diluted EPS was calculated using the “if-converted” method in relation to the 2.000% exchangeable senior notes due 2026, or the 2026 Notes. In July 2024, we made the irrevocable election to net share settle the 2026 Notes. As a result, the assumed issuance of ordinary shares upon exchange of the 2026 Notes has only been included in the calculation of diluted EPS, on a GAAP and non-GAAP adjusted basis, up to the date the irrevocable election was made. Diluted EPS, on a GAAP and non-GAAP adjusted basis, for the three and nine months ended September 30, 2024 included 1.3 million shares and 4.7 million shares, respectively, related to the assumed conversion of the 2026 Notes and the associated interest expense, net of tax, add-back, to GAAP reported net income and non-GAAP adjusted net income, for the three and nine months ended September 30, 2024 of $1.0 million and $10.8 million, respectively.2. Integration related expenses with respect to the Chimerix acquisition.JAZZ PHARMACEUTICALS PLCRECONCILIATIONS OF GAAP REPORTED TO NON-GAAP ADJUSTED INFORMATION – CERTAIN LINE ITEMS(In thousands, except percentages)(Unaudited) Three months ended September 30, 2025 Cost of Gross SG&A R&D Intangible Acquired Interest Income tax Effective product margin asset IPR&D expense, benefit tax rate sales amortization netGAAP Reported $ 128,880 87.9% $ 530,647 $ 198,203 $ 168,368 $ 42,500 $ 48,576 $ (242,424) N/A(1)Non-GAAP Adjustments:Intangible asset – – – – (168,368) – – – -amortizationShare-based (5,063) 0.5 (61,295) (21,767) – – – – -compensation expenseAcquisition accounting (40,355) 3.8 – – – – – – -inventory fair value step-upIntegration related (286) – (9,291) (6,459) – – – – -expensesIncome tax effect of – – – – – – – 63,643 N/A(1)above adjustmentsTotal of non-GAAP (45,704) 4.3 (70,586) (28,226) (168,368) – – 63,643 N/A(1)adjustmentsNon-GAAP Adjusted $ 83,176 92.2% $ 460,061 $ 169,977 $ – $ 42,500 $ 48,576 $ (178,781) (55.5)%

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1. Not a meaningful metric due to minimal GAAP profit before tax in this period. Three months ended September 30, 2024 Cost of Gross SG&A R&D Intangible Interest Income tax Effective product margin asset expense, expense tax rate sales amortization net (benefit)GAAP Reported $ 111,611 88.7% $ 325,772 $ 199,919 $ 157,457 $ 58,702 $ (14,533) (7.2)%Non-GAAP Adjustments:Intangible asset – – – – (157,457) – – -amortizationShare-based (3,733) 0.4 (37,100) (18,927) – – – -compensation expenseAcquisition accounting (35,034) 3.5 – – – – – -inventory fair value step-upIncome tax effect of – – – – – – 54,947 16.1above adjustmentsTotal of non-GAAP (38,767) 3.9 (37,100) (18,927) (157,457) – 54,947 16.1adjustmentsNon-GAAP Adjusted $ 72,844 92.6% $ 288,672 $ 180,992 $ – $ 58,702 $ 40,414 8.9%JAZZ PHARMACEUTICALS PLCRECONCILIATIONS OF GAAP REPORTED TO NON-GAAP ADJUSTED INFORMATION – CERTAIN LINE ITEMS(In thousands, except percentages)(Unaudited) Nine months ended September 30, 2025 Cost of Gross SG&A R&D Intangible Acquired Interest Income tax Effective product margin asset IPR&D expense, benefit tax rate sales amortization netGAAP Reported $ 349,768 87.9% $ 1,403,059 $ 568,827 $ 484,919 $ 947,862 $ 149,645 $ (277,406) 33.2%Non-GAAP Adjustments:Intangible asset – – – – (484,919) – – – -amortizationShare-based (12,963) 0.5 (143,968) (63,348) – – – – -compensation expenseIntegration related (286) – (16,369) (8,749) – – – – -expensesAcquisition accounting (107,344) 3.7 – – – – – – -inventory fair value step-upIncome tax effect of – – – – – – – 177,310 N/A(1)above adjustmentsTotal of non-GAAP (120,593) 4.2 (160,337) (72,097) (484,919) – – 177,310 N/A(1)adjustmentsNon-GAAP Adjusted $ 229,175 92.1% $ 1,242,722 $ 496,730 $ – $ 947,862 $ 149,645 $ (100,096) N/A(1)

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1. Not a meaningful metric due to minimal non-GAAP profit before tax in this period. Nine months ended September 30, 2024 Cost of Gross SG&A R&D Intangible Acquired Interest Income tax Effective product margin asset IPR&D expense, expense tax rate sales amortization net (benefit)GAAP Reported $ 317,000 88.7% $ 1,016,007 $ 643,500 $ 468,410 $ 10,000 $ 186,841 $ (33,517) (9.9)%Non-GAAP Adjustments:Intangible asset – – – – (468,410) – – – -amortizationShare-based (10,375) 0.4 (112,450) (55,030) – – – – -compensation expenseAcquisition accounting (97,220) 3.4 – – – – – – -inventory fair value step-upIncome tax effect of above – – – – – – – 161,045 21.7adjustmentsTotal of non-GAAP adjustments (107,595) 3.8 (112,450) (55,030) (468,410) – – 161,045 21.7Non-GAAP Adjusted $ 209,405 92.5% $ 903,557 $ 588,470 $ – $ 10,000 $ 186,841 $ 127,528 11.8%JAZZ PHARMACEUTICALS PLCRECONCILIATION OF 2025 GAAP NET LOSS AND DILUTED LPS TO NON-GAAP ADJUSTED NET INCOME AND DILUTED EPS GUIDANCE(In millions, except per share amounts)(Unaudited) Net Income (Loss) Diluted EPS/(LPS)GAAP $(435) – $(315) $(7.10) – $(5.20)Intangible asset amortization 610 – 660 9.85 – 10.65Share-based compensation expense 280 – 300 4.50 – 4.85Acquisition accounting inventory fair value step-up 135 – 155 2.15 – 2.50Integration related expenses 25 – 35 0.40 – 0.55Income tax effect of above adjustments (210) – (240) (3.40) – (3.85)Effect of potentially dilutive ordinary shares on non-GAAP adjusted EPS – 0.10 – 0.15Non-GAAP adjusted $475 – $525 $7.65 – $8.45Weighted-average ordinary shares used in per share calculations – GAAP 61Weighted-average ordinary shares used in per share calculations – non-GAAP 62

Contacts:

Investors:Jack SpinksExecutive Director, Investor RelationsJazz Pharmaceuticals plcInvestorInfo@jazzpharma.comIreland +353 1 634 3211U.S. +1 650 496 2717

Media:Kristin BhavnaniHead of Global Corporate CommunicationsJazz Pharmaceuticals plcCorporateAffairsMediaInfo@jazzpharma.comIreland +353 1 637 2141U.S. +1 215 867 4948

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