The Heart Failure Society of America (HFSA) is pleased to announce the Late Breaking Clinical Research that will be presented at its Annual Scientific Meeting (ASM),September 26-29, at the at the Minneapolis Convention Center in Minneapolis, MN.
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Late breaking clinical researchto be featured during two plenary sessions includes results and updates from these major randomized trials:
Sunday, September 28 Plenary Session | 9:00 AM – 10:30 AMLate Breaking Clinical Research 1: Devices and Cardiomyopathies
— Integra-D Trial
— Effects of a Novel Cardiac Contractility Modulation-Defibrillator (CCM-D) on NYHA Functional Class in ICD-Indicated Patients: Post-Implant Results from the Integra-D Trial
— FUTURE-HF
— Development of an Individualized Congestion Score using a NovelImplantable Inferior Vena Cava Sensor: the FUTURE-HF Trial Portfolio
— DETECT-HF
— Development and Training of a Voice-Based Algorithm for Heart Failure Monitoring: Performance results from 599 Patients over 360,000 Patient-Days
— FOREST-HCM
— Safety and Efficacy ofAficamten in Patients with Nonobstructive Hypertrophic Cardiomyopathy: a 96-week analysis from FOREST-HCM
— MAPLE-HCM
— Divergent Effect ofAficamten Versus Metoprolol on Exercise Performance in Obstructive Hypertrophic Cardiomyopathy: A Prespecified Analysis of MAPLE-HCM
— ATTRibute-CM
— Acoramidis Reduces Cumulative Cardiovascular Outcomes Within the First Month of Treatment in Transthyretin Amyloid Cardiomyopathy: Results From ATTRibute-CM
— HELIOS-B
— Reduction in Gastrointestinal Events inATTR-CM Patients Treated with Vutrisiran Compared with Placebo: Analysis from HELIOS-B
Monday, September 29 Plenary Session | 9:00 AM – 10:30 AMLate Breaking Clinical Research 2: Novel Therapies
— VICTOR Trial
— Vericiguat Efficacy and Safety Across Baseline Background Therapy in Contemporary Ambulatory Patients with HFrEF Enrolled in the VICTOR trial
— Tolerability and Safety ofVericiguat in Chronic Heart Failure with Reduced Ejection Fraction
— SEISMiC C
— Safety and Efficacy of Intravenous Administration ofIstaroxime for 48 hours in Patients with SCAI C Cardiogenic Shock due to Acute Heart Failure
— SUMMIT Trial
— Effects ofTirzepatide in Obesity-Related HFpEF by Sex: A Prespecified Secondary Analysis from the SUMMIT Trial
— GARDEN TIMI-74
— GDF-15 Neutralization in Patients with Heart Failure: Primary Results of theGARDEN-TIMI 74 Trial
— Danicamtiv Trial
— Danicamtiv Restores Ventricular and Atrial Function in Patients with Dilated Cardiomyopathy Caused by Genetic Variants that Depress Sarcomere Function
Late Breaking Clinical Research showcases novel results of major randomized trials and rapidly evolving research. Due to the quantity of remarkable trials submitted, HFSA will also feature late breaking research through Rapid Fire Oral Sessions. These Rapid Fire sessions are fast-paced oral presentations spotlighting key data from late breaking clinical research. Sessions take place on Sunday and Monday with Q&A and new topics each day.
Sunday September 28 | Rapid Fire 1 | 10:45 AM – 11:45 AM
— Phase 1 Study ofDaratumumab-Hyaluronidase for Reduction of Circulating Antibodies in Patients with High Allosensitization Awaiting Heart Transplantation
— Safety of Sodium-GlucoseCotransporter 2 Inhibitors in Post-Heart Transplant Patients: A Multi-Center Retrospective Cohort Study
— Long Term Outcomes afterLVAD Weaning for Myocardial Recovery: Results from the VAD Wean Recovery Network
— First-In-Human Implantation of a Next-Generation Membrane-BasedLVAD
— Long Term Trajectory ofGlomerular Filtration Rate Post-LAVD and the Impact on Clinical Outcomes: An analysis of the MOMEMTUM 3 Study
— IncreasedLVEF at Six Months Following LVAD Implant is Associated with Improved Long-Term Outcomes – A MOMENTUM-3 Analysis
— Screening for advanced heart failure in stable outpatients (The SAINTS study)
Sunday, September 28 | Rapid Fire 2: | 2:15 PM – 3:15 PM
— Clinical Outcomes for Heart Failure at High Risk ofHyperkalemia according to Optimization of Agents Targeting the Renin-Angiotensin-Aldosterone System
— Intravenous FerricCarboxymaltose in Patients With Ischemic Versus Non-Ischemic Etiology of Heart Failure and Iron Deficiency
— Residual Risk ofHyperkalemia Among Patients with Heart Failure Treated with SGLT2i and ARNI Instead of ACEI/ARB
— High-Dose IV Loop Diuretic Therapy andOtotoxicity Risk in Patients with Acute Heart Failure: Insights from the FASTR Trial
— Expanded Results from a Guideline-Directed Medical Therapy Clinic
— Optimized Heart Failure Therapy in Patients at Risk of Cardiac Wasting in Patients with Advanced Cancer: Results from theEMPATICC trial
— Supervised Exercise Training Improves Outcomes in Heart Failure: Evidence from thePACT-HF 2×2 Factorial Trial
Sunday, September 28 | Rapid Fire 3 | 4:15 PM – 5:15 PM
— Cardiac Contractility Modulation Reduces Mortality and Heart Failure Hospitalizations: A Matched Comparison of Patients Receiving and Not ReceivingCCM Derived from a Real-World Dataset
— PROACTIVE-HF: 2-year outcomes, stratified by LVEF
— Outcomes of Poor Clinical Responders AfterTranscatheter Aortic Valve Replacement in Older Patients
— InvasiveHemodynamic Risk Stratification and Transcatheter Edge-to-Edge Tricuspid Repair: One-Year Results from TRILUMINATE Pivotal Trial
— Relationship between changes in seated pulmonary artery pressure, blood pressure, heart rate, and weight prior to heart failure hospitalization
— A Randomized Trial of a Remote, Digital Intervention Targeting Heart Failure Medical Therapy
— Machine-Learning Estimation of Pulmonary Capillary Wedge and Right Atrial Pressures With a Non-invasiveMultisensor Device
— Deep learning assisted prediction for occurrence of pacing-inducedcardiomyopathy in the atrio-ventricular block
Monday, September 29 | Rapid Fire 4 | 12:00 PM – 1:00 PM
— Effect ofvericiguat, compared with placebo, across baseline risk categories in chronic heart failure with reduced ejection fraction in the VICTOR Trial
— Effect ofVericiguat on Heart Failure Hospitalisation Events in Ambulatory Patients with Heart Failure and Reduced Ejection Fraction: VICTOR Trial Prespecified Analysis
— Effect ofVericiguat on Mortality in Ambulatory Patients with Heart Failure and Reduced Ejection Fraction: VICTOR Trial Prespecified Analysis
— Regional Variation in Outcomes and Response toVericiguat in Heart Failure with Reduced Ejection Fraction: The VICTOR Trial
— Effect of the SolubleGuanylate Cyclase Stimulator Vericiguat on Health Status in the Phase 3 VICTOR Trial
— The Effect ofVericiguat on Mode of Death in Patients with Heart Failure with Reduced Ejection Fraction in the VICTOR Trial
— Rapidity of benefit of simultaneous initiation offinerenone and empagliflozin in people with chronic kidney disease and type 2 diabetes: the CONFIDENCE trial
— Dapagliflozin in Patients with Heart Failure: A Meta-Analysis of DAPA-HF, DELIVER, and DAPA ACT HF-TIMI 68
The meeting kicks off in just three weeks. A full schedule at a glance is available online, as well as information on the science and researchand networkingavailable at the meeting. Learn more about the meeting and register at hfsa.org/asm2025.
About the Heart Failure Society of America
The Heart Failure Society of America, Inc. (HFSA) represents the first organized effort by heart failure experts from the Americas to provide a forum for all those interested in heart function, heart failure, and congestive heart failure (CHF) research and patient care. The mission of HFSA is to provide a platform to improve and expand heart failure care through collaboration, education, innovation, research, and advocacy. HFSA members include physicians, scientists, nurses, nurse practitioners, pharmacists, trainees, other healthcare workers and patients. For more information, visit hfsa.org.
Media Contact: Laura Poko, 301-798-4493, ext. 226, lpoko@hfsa.org
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