The TYK2 inhibitor market is expected to witness substantial growth in the coming years, driven by the increasing prevalence of autoimmune diseases, robust clinical pipeline activity, and expanding regulatory approvals. Several key players, including Takeda, Alumis, Priovant Therapeutics, and others, are involved in developing drugs for TYK2 inhibitors, such as Crohn's disease, psoriasis, dermatomyositis, and others, respectively.
DelveInsight'sTYK2 Inhibitors Market Size, Target Population, Competitive Landscape & Market Forecastreport includes a comprehensive understanding of current treatment practices, addressable patient population, which includes top indications such as SLE, Crohn's disease, Hidradenitis suppurativa, Psoriatic Arthritis, Dermatomyositis, and others. The selected indications are based on approved therapies and ongoing pipeline activity. The report also provides insights into the emerging TYK2 inhibitors, market share of individual therapies, and current and forecasted market size from 2020 to 2034, segmented into 7MM.
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Key Takeaways from the TYK2 Inhibitors Market Report
— As per DelveInsight's analysis, the total market size of TYK2 inhibitorsin the 7MM is expected to surge significantly by 2034.
— The market size of SOTYKTU was USD 190 million in the US in 2024, with a 32% year-over-year increase.
— The report provides the total potential number of patients in the indications, such as SLE, Crohn's disease, Hidradenitis suppurativa, Psoriatic Arthritis, Dermatomyositis, and others.
— Leading TYK2 inhibitorcompanies, such as Priovant Therapeutics, Takeda, Alumis, Galapagos, Oncostellae, Neuron23, and others, are developing novel TYK2 inhibitorsthat can be available in the TYK2 inhibitorsmarket in the coming years.
— Some of the key TYK2 inhibitorsin the pipeline include Brepocitinib, Zasocitinib, ESK-001, GLPG3667, OST-122, NEU-111, and others.
— In March 2025, Alumis and Kaken Pharmaceutical entered into a collaboration and licensing agreement to develop, manufacture, and commercialize ESK-001 for dermatology indications in Japan, with the option to expand the license to include rheumatological and gastrointestinal diseases.
— In December 2024, Bristol Myers Squibb announced results from the POETYK PsA-1 (IM011-054) and POETYK PsA-2 (IM011-055) Phase III trials, which assessed the efficacy and safety of SOTYKTU (deucravacitinib) in adults with active psoriatic arthritis.
Discover which indication is expected to grab the major TYK2 inhibitors market share @ TYK2 Inhibitors Market Report
TYK2 Inhibitors Market Dynamics
The market for TYK2 inhibitors is emerging as a dynamic and rapidly evolving segment within the broader immunology and inflammation therapeutics space. Unlike broader JAK inhibitors that often target multiple JAK subtypes and are associated with off-target effects and safety concerns, selective TYK2 inhibitors offer a more targeted approach, potentially minimizing adverse effects while maintaining efficacy. This selectivity is a key driver of pharmaceutical interest and investor confidence in this class of drugs.
Deucravacitinib, developed by Bristol Myers Squibb, is the first and most prominent TYK2 inhibitor to receive regulatory approval, having been cleared by the FDA for the treatment of moderate-to-severe plaque psoriasis. Its oral once-daily administration and favorable safety profile compared to JAK inhibitors have set a benchmark in the field, paving the way for other TYK2 inhibitors in clinical development. Several companies are actively advancing their own TYK2 candidates, targeting a broader range of autoimmune indications and hoping to capitalize on the differentiated profile of this class.
Market dynamics are being shaped not only by clinical progress but also by regulatory and payer scrutiny. As TYK2 inhibitors are closely related to JAK inhibitors, regulators have shown heightened vigilance regarding their safety, particularly around immunosuppression, cardiovascular events, and malignancies. However, early data from selective TYK2 inhibitors suggest they may avoid some of the black box warnings attached to JAK inhibitors, which could offer a competitive edge in terms of market access and physician preference. Nevertheless, long-term real-world data will be crucial to cement their positioning as safer alternatives.
Commercial uptake will also be influenced by competitive pressures from biologics and newer small molecules across different autoimmune disease indications. For instance, in psoriasis, TYK2 inhibitors compete against well-established biologics like IL-17 and IL-23 inhibitors, which have demonstrated high efficacy. However, the convenience of oral administration and lower manufacturing costs give TYK2 inhibitors a potential edge in less severe disease segments or in markets with limited access to biologics. Pricing strategies, payer negotiations, and inclusion in treatment guidelines will all play a vital role in determining the extent of market penetration.
TYK2 Inhibitors Treatment Market
Tyrosine kinase 2 inhibitors are being developed as effective therapies for a range of immune-mediated conditions, including psoriasis, psoriatic arthritis, hidradenitis suppurativa, inflammatory bowel disease (IBD), dermatomyositis, Crohn's disease, systemic lupus erythematosus (SLE), ulcerative colitis, and others.
Currently, the only approved TYK2 inhibitor is Bristol-Myers Squibb's SOTYKTU (deucravacitinib). SOTYKTU is a selective allosteric inhibitor that targets the regulatory domain of TYK2, a member of the Janus kinase family. By binding to this domain, SOTYKTU stabilizes the inhibitory interaction between the regulatory and catalytic domains of TYK2, leading to suppression of receptor-driven activation and downstream signaling through STAT proteins, as demonstrated in cellular assays.
TYK2 typically dimerizes with JAK1 to drive multiple cytokine signaling pathways and also partners with JAK2 in certain contexts. Although the exact mechanism by which TYK2 inhibition produces clinical benefit in moderate-to-severe plaque psoriasis remains unclear, SOTYKTU has received approval for use in adults with this condition who are eligible for systemic therapy or phototherapy.
Learn more about the TYK2 inhibitors@ TYK2 Inhibitors Analysis
Key Emerging TYK2 Inhibitors and Companies
Several companies, including Priovant Therapeutics (brepocitinib), Alumis (ESK-001), Galapagos (GLPG366), Takeda (zasocitinib), and others, are engaged in the development of TYK2 inhibitors.
ESK-001is a TYK2 inhibitor that blocks signaling from several cytokine receptors, including those for interleukin-23 (IL-23) and type 1 interferons. By targeting key pro-inflammatory pathways involved in the development of systemic lupus erythematosus (SLE), ESK-001 may help lower disease activity. The drug is currently undergoing evaluation in a Phase II clinical trial.
Priovant's lead candidate, brepocitinib, is an oral, once-daily dual inhibitor of TYK2 and JAK1. Its selective inhibition of both pathways is designed to broadly suppress cytokine signaling associated with autoimmune conditions, including type I and type II interferons, IL-6, IL-12, and IL-23.
Priovant is advancing brepocitinib in multiple serious autoimmune indications. The drug is being tested in the VALOR Study, a fully enrolled registrational Phase III trial in dermatomyositis, with top-line data anticipated in 2025. In addition, Priovant has launched the Phase III CLARITY Study in non-infectious uveitis (NIU) following promising Phase II results from the NEPTUNE Study. A Phase II trial of brepocitinib in cutaneous sarcoidosis is also planned for 2025.
The anticipated launch of these emerging therapies are poised to transform the TYK2 inhibitors market landscape in the coming years. As these cutting-edge therapies continue to mature and gain regulatory approval, they are expected to reshape the TYK2 inhibitors market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth.
To know more about TYK2 inhibitors clinical trials, visit @ TYK2 Inhibitors Treatment
TYK2 Inhibitors Overview
TYK2, a member of the Janus kinase (JAK) family, plays a crucial role in pro-inflammatory signaling pathways within both the innate and adaptive immune systems. Its activation is thought to be key in driving cellular mechanisms linked to the onset and progression of autoimmune diseases. Unlike broader JAK inhibitors, selectively targeting TYK2 may lead to fewer side effects. TYK2 inhibitors are a class of drugs designed to block the activity of this specific enzyme, which is involved in immune responses and inflammation. By doing so, they aim to alleviate inflammation and its symptoms. These inhibitors are under investigation for their potential in treating several autoimmune conditions, such as psoriasis, psoriatic arthritis, inflammatory bowel disease (IBD), and others.
TYK2 Inhibitors Epidemiology Segmentation
The TYK2 inhibitors market report proffers epidemiological analysis for the study period 2020-2034 in the 7MM, segmented into:
— Total Cases in Selected Indications for TYK2 inhibitors
— Total Eligible Patient Pool in Selected Indications for TYK2 inhibitors
— Total Treated Cases in Selected Indications for TYK2 inhibitors
Scope of the TYK2 InhibitorsMarket Report
— TYK2 Inhibitors Therapeutic Assessment: TYK2 Inhibitors' current marketed and emerging therapies
— TYK2 InhibitorsMarket Dynamics: Conjoint Analysis of Emerging TYK2 InhibitorDrugs
— Competitive Intelligence Analysis:SWOT analysis and Market entry strategies
— Unmet Needs, KOL's views, Analyst's views, TYK2 Inhibitors Market Access and Reimbursement
Discover more about TYK2 inhibitors in development @ TYK2 Inhibitors Clinical Trials
Table of Contents
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